Contour-informed inter-patient deformable registration for more reliable voxel-based analysis of Head-and-Neck cancer patients
Jan 1, 2026·
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Xingyue Ruan
Xia Li
Muheng Li
Barbara Bachtiary
Antony J. Lomax
Zhiling Chen
Ye Zhang
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Abstract
The registration of individual dose distributions to a reference anatomy represents a key step in voxel-based analysis (VBA), a tool for spatially informed dose–response assessment. Accurate deformable image registration (DIR) is essential for addressing anatomical variability across patients. To improve both global and region-specific alignment, we enhanced our in-house DIR algorithm (CPT-DIR) by incorporating contour-informed regularization.
Type
Publication
Physics and Imaging in Radiation Oncology
